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59 2023-03-18
KºƬôKºƬôʹt(y)ˎW(wng)ѼPKºƬf,KºƬr,KºƬX,KºƬĹЧc,KºƬ÷cˎƷϢȫԃʹ
ƷQ:KºƬ
̖:ˎ400013H12
:1.mίɄ}Ӳ}Ѫ˨]}סµԄ}]Y2.Ʒܸ֫wȱѪԝʹl(f)估gЪί(ѪܳgѪֲg(jng)гg)aίԾYѭh(hun)ֲѪ܃(ni)Ѫ˨γ
÷:ڷˣһ50100mgһ2Σp߿ɸ(j)YҪrmӄ
ͨQ
Ƭ
Σ
?1.mίɄ}Ӳ}סѪ˨]}µԄ}]Y
2.Ʒܸ֫wȱѪԝʹl(f)估gЪί(ѪܳgѪֲg(jng)гg)aίԾYѭh(hun)ֲѪ܃(ni)Ѫ˨γ
÷
ڷˣһ50100mgһ2Σp߿ɸ(j)YҪrmӄ
1.Ҫ^ʹ^ļµe߿ɳF(xin)Ѫƫ
2.Ξ鸹ÛI¡θmʹY
3.ٔ(sh)F(xin)ιܮlصֵ
4.żҊ^ƤW
5.żаpƤ³ѪѪdzѪѪ۵׳ѪȈ
ɣ
ѪԼ(ѪѲëѪܴԼԝѪѪӌmԳѪȻѪA)
ע헣
1.Ⱥã
(1)ڷˎѷÿѪСˎ(簢˾ƥƥ);
(2)ظIܲȫ;
(3)ЇغϲY琺[;
(4)p;
(5)^w|(zh)Nˎ^^Լߡ
2.ƷѪˎgӏԭпѪί
ɷݣ
ƷҪɷ֞
ЋDڋDŮˎ
PڋDŮӋ/ċDŮ
ͯˎ
׃ˎİȫδ_
ˎã
ǰE1cƷf(xi)ͬӼ(ni)h(hun)նЧ
ˎã
1ѪС
1w⣨invitro
a.СȮ˵ѪСADPzԭϩᡢIصȌµѪСۼ
b.wѪСADPI،µѪСһξۼ߀нxTӌµѪСۼK
2w(ni)invivo
a.ȮMпڷoˎԇADPzԭµѪСۼ
b.Ԅ}]Y߿ڷADPzԭϩIصȌµѪСۼ
c.woˎѸٮa(chn)ѪСۼBm(x)ҲɾSЧp
d.ͣñƷʹƵѪСۼSƷѪˎȵ˥p֏͵oˎǰֵδl(f)F(xin)зF(xin)ۼM
2Ѫ˨
o}Сw(ni)עADPzԭTl(f)ķ˨
ȮĹɄ}ע¹cTl(f)Ѫ˨֫ѭh(hun)ȫMչ
ƌȮĹɄ}ÓQ˹ѪTl(f)ľֲѪ˨˨Y
3ѪܔU
tKC1ǰF2aµȮxwɄ}ա
ȮĹɄ}Ѫ
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Mһͨ^^쵽֫ƤwضƤwѪ
4ÙC
ƷƼѪС5-uɫጷӰѪС匦5-uɫյĔzȡѪСĻϩx]Ӱͨ^Ѫ˨A2(TXA2)ѪСۼ
Ʒͨ^ѪС弰Ѫƽ(ni)ĭh(hun)øĶl(f)]ѪСüѪܔUá